In 2003-2013 period, the number of patents and trademarks filed per 100,000 inhabitants in Lazio, Lombardy e Piedmont has respectively decreased of -40% for the formers and -35% for the latter. Differently, the same parameter has considerably increased in Emilia-Romagna (+130%), Friuli-Venezia Giulia (+155%), Trentino-Alto Adige(+215%) and Marche(+248%). Indeed, these are the Italian regions with the highest quantity of innovative start-ups upon the total number of the limited companies, which reaches 72% in Trentino-Alto Adige. This short account implies that investments in innovation are pushed by small and medium-sized enterprises, demonstrating to be more competitive than big companies, which are all along based in Piedmont and Lombardy. Anyway, Milan’s region continues to be the most innovative one, in both relative and absolute terms.